Neil E. Williams develops a systematic metaphysics centred on the idea of powers, as a rival to neo-Humeanism, the dominant systematic metaphysics in philosophy today. Williams takes powers to be inherently causal properties and uses them as the foundation of his explanations of causation, persistence, laws, and modality.

Central to the debate between Humean and anti-Humean metaphysics is the question of whether dispositions can exist in the absence of categorical properties that ground them (that is, where the causal burden is shifted on to categorical properties on which the dispositions would therefore supervene). Dispositional essentialists claim that they can; categoricalists reject the possibility of such ?baseless? dispositions, requiring that all dispositions must ultimately have categorical bases. One popular argument, recently dubbed the ?Argument from Science?, has appeared in one (...) or another form over much of the last century and purports to win the day for the dispositional essentialist. Taking its cue from physical theory, the Argument from Science treats the exclusively dispositional characterizations of the fundamental particles one finds in physical theory as providing a key premise in what has been called a ?decisive? argument for baseless dispositions. Despite sharing the intuition that dispositions can be baseless, I argue that the force and significance of the Argument from Science have been greatly overestimated: no version of the argument is close to decisive, and only one version succeeds in scoring points against the categoricalist. Not only is physical theory more ontologically innocent than defenders of baseless dispositions seem to appreciate, most versions of the Argument from Science neglect important ways that dispositions could be grounded by categorical properties. (shrink)

Power theorists are divided on the question of whether individual powers are single-track (for a single manifestation type) or are multi-track (capable of producing distinct manifestation types for distinct stimuli). EJ Lowe has recently defended single-tracking, arguing that the multi-tracker can provide no adequate reason for treating powers as capable of having multiple manifestation types, and claiming that putative instances of multi-track powers are either single-track powers in need of unifying descriptions or are merely several single-track powers. I respond to (...) Lowe on behalf of the multi-tracker, first by arguing that he overlooks the extra-empirical features of the debate, then by posing a dilemma for any single-track account of powers concerning the single-tracker’s ability to appropriately deal with fine-grained manifestation types. Finally I provide the aforementioned reason for thinking that there are multi-track powers. (shrink)

Recently, several philosophers have defended what might be called `neo-essentialism' about natural kinds. Their views purport to improve upon the traditional essentialism of Kripke and Putnam by rejecting the claim that essences must be comprised of intrinsic properties. I argue that this so-called break from traditional essentialism is not a break at all, because the widespread interpretation of Putnam according to which he takes essences to be intrinsic is mistaken. Putnam makes no claim to the effect that essences of natural (...) kinds must be intrinsic, and offers at least one example of a natural kind whose essence is non-intrinsic. I conclude that his traditional essentialism has been misinterpreted, and consequently that neo-essentialism is not so `neo' after all. (shrink)

This chapter focuses on the view that diseases comprise natural kinds and how this view is in conflict with the essentialist picture of natural kinds as championed by Kripke and Putnam. This essentialist depiction of natural kinds contends that in order for a class of entities to be a natural kind, it is required that all and only members of the class instantiate very specific properties that explain the presence of any other properties typically associated with being a member of (...) the kind; these privileged properties constitute the “essence” of the kind. The problem is that the essentialist picture provides only two options, none of which is desirable: satisfy the essentialist desiderata by locating some etiological feature both necessary and sufficient for kind membership, or reject the thought that similarity between disease instances can be understood in terms of natural kinds. (shrink)

– The paper defends a naturalistic version of modal actualism according to which what is metaphysically possible is determined by dispositions found in the actual world. We argue that there is just one world—this one—and that all genuine possibilities are anchored by the dispositions exemplified in this world. This is the case regardless of whether or not those dispositions are manifested. As long as the possibility is one that would obtain were the relevant disposition manifested, it is a genuine possibility. (...) Furthermore, by starting from actual dispositional properties and branching out, we are able to include possibilities that are quite far removed from any state of affairs that happens to obtain, while still providing a natural and actual grounding of possibility. Stressing the importance of ontological considerations in any theory of possibility, it is argued that the account of possibility in terms of dispositional properties provides a more palatable ontology than those of its competitors. Coming at it from the other direction, the dispositional account of possibility also provides motivation for taking an ontology of dispositions more seriously. As well as the relevant dispositional notions required to lay out the view, the paper discusses the dispositional realism needed as the basis for the account of possibility. (shrink)

The aim of the paper is to give an ontologically informed account of disease that can aid in the construction of disease ontologies. The paper begins by distinguishing cases of diseases from what are purely structural abnormalities, referred to as ‘disorders’. The paper then presents a causal model apt for the understanding of disease that distinguishes diseases from both their causes and their potential effects. The analysis of disease defended treats disease in terms of distortions of standard cellular network processes, (...) where those distortions are incapable of self remedy and produce biologically disadvantageous symptoms. (shrink)

Powers theorists frequently assert that their neo-Aristotelian frameworks are dynamic, and that this gives them a theoretical advantage over their neo-Humean rivals. But recently it’s been claimed that activity can also be used to divide powers theories themselves. Dynamism is here understood primarily in terms of activity: a metaphysic counts as dynamic according to the place activity is given within the system. Activists treat activity as fundamental or irreducible, and claim to have the philosophical high ground over those ‘passivist’ powers (...) theories wherein activity is reducible or nonfundamental. In this paper I take a closer look at dynamism within powers theories, with a particular focus on how the activism/passivism distinction might be made. I then consider the broader ontological impact that the various commitments to activity might carry, along with an assessment as to who appears to be better off. Despite what’s been claimed, I find no reason to think that activists have any serious theoretical advantage in this debate. In fact, as things presently stand, I am not convinced that powers and activity make for a good pairing at all, as there’s presently no good model for powers like this. (shrink)

I raise a puzzle case for “cluster” accounts of natural kinds—the homeostatic property cluster and stable property cluster accounts, especially—on the basis of their expected treatment of the metaphysics of certain disease kinds. Some kinds, I argue, fail to exhibit the co-instantiated property clusters these cluster views take to be constitutive of natural kinds. Some genetic diseases, for example, have archetypical instances with few or none of the pathological processes or symptoms associated with the kind: their instances are typified by (...) a single dispositional property. I dub such kinds ‘amorphic’, owing to their limited morphology, and try out a number of ways in which these kinds might be treated in terms of property clusters, adapting responses cluster theorists have offered to the problem of polymorphic species. Finding these responses wanting, I conclude that cluster accounts are unlikely to be the best account of the metaphysics of amorphic kinds. (shrink)

John Heil’s From an Ontological Point of View (Heil 2003) is a tremendous philosophical work. The neo-Lockean ontology the reader finds within its 267 pages is a sensible and refreshing alternative to the neo-Humean ontologies which presently occupy the vast majority of the metaphysical literature. What Heil offers is a much needed change in perspective. Nor are the strengths of the book limited to Heil’s willingness to approach central metaphysical problems in largely untried and unpopular way; the book is very (...) clear in its presentation, accessible to wide readership, and tightly argued throughout. Heil’s efforts in this book are to be applauded, and the result is one that warrants serious consideration by all those interested in serious metaphysics. But the interest should not end there: the lessons of Heil’s book are ones that almost all philosophers ought to take seriously. Despite the criticism that follows, my overall position should not be taken as anything short of a whole-hearted endorsement of Heil’s book. Nonetheless, when philosophy is one’s trade, there is always going to be something to disagree about, however much one is amenable to a view. (shrink)

The paper defends a naturalistic version of modal actualism according to which what is metaphysically possible is determined by dispositions found in the actual world. We argue that there is just one world – this one – and that all genuine possibilities are grounded in the dispositions exemplified in it. This is the case whether or not those dispositions are manifested. As long as the possibility is one that would obtain were the relevant disposition manifested, it is a genuine possibility. (...) Furthermore, by starting from actual dispositional properties and branching out, we are able to countenance possibilities quite far removed from any state of affairs that happens to obtain, while still providing a natural and actual grounding of possibility. Stressing the importance of ontological considerations in any theory of possibility, it is argued that the account of possibility in terms of dispositional properties provides a more palatable ontology than those of its competitors. Coming at it from the other direction, the dispositional account of possibility also provides motivation for taking an ontology of dispositions more seriously. (shrink)

Dispositional Pluralism By McKitrickJenniferOxford University Press, 2018. iv + 262 pp.

Environmental actions require a willingness to act, which, in turn, is stimulated partially by the belief that an action will yield the desired consequences. In determining whether an actor was justified in exerting the will to act, therefore, it is essential to examine the nature of evidence offered by the actor in support of any beliefs about the environment. In this paper we explore the points in environmental risk analyses at which evidence is brought to bear in support of inferences (...) conceming environmental effects of regulatory actions. The intent is to provide a framework for discussing the manner in which evidence may provide a sufficient basis for ethically sound decisions for environmental actions. (shrink)

Using a two-part instrument consisting of eight vignettes and twenty character traits, the study sampled 141 employees of a mid-west financial firm regarding their predispositions to prefer utilitarian or formalist forms of ethical reasoning. In contrast with earlier studies, we found that these respondents did not prefer utilitarian reasoning. Several other hypotheses were tested involving the relationship between people's preferences for certain types of solutions to issues and the forms of reasoning they use to arrive at those solutions; the nature (...) of the relationship between utilitarian and formalist categories ; and the possibility of measuring ethical predispositions using different methods. (shrink)

Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together (...) researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals. (shrink)

Software plays an important role in contemporary research. Aside from its use for administering traditional instruments like surveys and in data analysis, the widespread use of mobile and web apps for social, medical and lifestyle engagement has led to software becoming a research intervention in its own right. For example, it is not unusual to find apps being studied for their utility as interventions in health and social life. Since the software may persist in use beyond the life of an (...) investigation, this raises questions as to the extent of ethical duties for researchers involved in its production and/or study towards the participants involved. Key factors identified include the extent of affect created by the software, the effect it has on a participant’s life, the length of investigation, cost of maintenance and participant agency. In this article we discuss the issues raised in such situations, considering them in the context of post-research duties of care and suggesting strategies to balance the burden on researchers with the need for ongoing participant support. (shrink)

The philosophy of patient-centred care has become widely embraced but its implementation is dependent on interrelated factors. A factor that has received limited attention is the role of policy tools. In Ontario, one method government can use to promote healthcare priorities is through health regulatory colleges, which set the standard of practice for health professionals. The degree to which government policy in support of patient-centered care has influenced the direction provided by health regulatory colleges to their members, and ultimately impacted (...) actual patient care, remains unclear. This study investigates the extent to which Ontario’s health regulatory colleges have provided explicit written guidance to members related to the importance of patient-centred care. It also explores applied and theoretical explanations that may further our understanding of why patient-centred care has not been more fully embraced. Findings reveal that guidance provided by Ontario’s health regulatory colleges varies widely. Institutional barriers and the choice of policy tools for disseminating government preferences may hinder full implementation of the principles of patient-centred care. More fully understanding the role health regulatory colleges’ play in facilitating the implementation of health policy will contribute positively to dialogue and to efforts to achieve positive health system reforms. (shrink)

I raise a puzzle case for “cluster” accounts of natural kinds—the homeostatic property cluster and stable property cluster accounts, especially—on the basis of their expected treatment of the metaphysics of certain disease kinds. Some kinds, I argue, fail to exhibit the co-instantiated property clusters these cluster views take to be constitutive of natural kinds. Some genetic diseases, for example, have archetypical instances with few or none of the pathological processes or symptoms associated with the kind: their instances are typified by (...) a single dispositional property. I dub such kinds ‘amorphic’, owing to their limited morphology, and try out a number of ways in which these kinds might be treated in terms of property clusters, adapting responses cluster theorists have offered to the problem of polymorphic species. Finding these responses wanting, I conclude that cluster accounts are unlikely to be the best account of the metaphysics of amorphic kinds. (shrink)

This paper offers an original solution to the problem of the many, built on a foundation of powers-based causation. At its most basic, the solution should be understood as a type of maximality response, and on those grounds its originality might be questioned. However, it is argued that novelty of the solution owes as much to the meta-metaphysical context in which the solution is framed as it does the model of causal powers. A discussion of paradigms in metaphysics is included.

This article focusses upon defining those factors which may contribute to the pathogenesis of cancer. The molecular basis of tumour etiology is discussed with reference to cancer predisposing syndromes, and in particular to the human inherited disease, Bloom's sysdrome. In Bloom's syndrome, patients are predisposed to a wide variety of malignant disease. We propose a model in which overexpression of the ubiquitous c‐myc proto‐oncogene contributes to this process.

BackgroundIn specific situations it may be necessary to make an exception to the general rule of informed consent for scientific research with an intervention. Earlier reviews only described subsets of arguments for exceptions to waive consent.MethodsHere, we provide a more extensive literature review of possible exceptions to the rule of informed consent and the accompanying arguments based on literature from 1997 onwards, using both Pubmed and PsycINFO in our search strategy.ResultsWe identified three main categories of arguments for the acceptability of (...) a consent waiver: data validity and quality, major practical problems, and distress or confusion of participants. Approval by a medical ethical review board always needs to be obtained. Further, we provide examples of specific conditions under which consent waiving might be allowed, such as additional privacy protection measures.ConclusionsThe reasons legitimized by the authors of the papers in this overview can be used by researchers to form their own opinion about requesting an exception to the rule of informed consent for their own study. Importantly, rules and guidelines applicable in their country, institute and research field should be followed. Moreover, researchers should also take the conditions under which they feel an exception is legitimized under consideration. After discussions with relevant stakeholders, a formal request should be sent to an IRB. (shrink)

Free radicals are generally perceived as highly reactive species which are harmful to biological systems. There are, however, a number of enzymes that use carbon‐based radicals to catalyse a variety of important and unusual reactions. The most prominent example is ribonucleotide reductase, an enzyme which is crucial for the synthesis of DNA. In general, radicals are used to remove hydrogen from unreactive positions in the substrate, and in this way the substrate is activated to undergo chemical transformations that would otherwise (...) be difficult to achieve. Several different mechanisms have evolved which allow enzymes to generate and maintain radicals in increasingly aerobic enviroments. An unexpected finding is the existance of stable protein‐based radicals, residing on a variety of amino‐acid side chains, which serve to link the radical‐generating and catalytic sites and to store the radical between turnovers. (shrink)

The philosophy of patient-centred care has become widely embraced but its implementation is dependent on interrelated factors. A factor that has received limited attention is the role of policy tools. In Ontario, one method government can use to promote healthcare priorities is through health regulatory colleges, which set the standard of practice for health professionals. The degree to which government policy in support of patient-centered care has influenced the direction provided by health regulatory colleges to their members, and ultimately impacted (...) actual patient care, remains unclear. This study investigates the extent to which Ontario’s health regulatory colleges have provided explicit written guidance to members related to the importance of patient-centred care. It also explores applied and theoretical explanations that may further our understanding of why patient-centred care has not been more fully embraced. Findings reveal that guidance provided by Ontario’s health regulatory colleges varies widely. Institutional barriers and the choice of policy tools for disseminating government preferences may hinder full implementation of the principles of patient-centred care. More fully understanding the role health regulatory colleges’ play in facilitating the implementation of health policy will contribute positively to dialogue and to efforts to achieve positive health system reforms. (shrink)

Although the genetic code is defined by a linear array of nucleotides, it is the three‐dimensional structure of the double helix that regulates most of its cellular functions. Over the past two decades, it has become increasingly clear that aspects of this three‐dimensionality which reflect topological relationships within the double helix (i.e., superhelical twisting, knotting, or tangling) influence virtually every facet of nucleic acid physiology. In vivo, DNA topology is modulated by ubiquitous enzymes known as topoisomerases. The type II enzyme (...) essential to the eukaryotic cell and is required for unlinking daughter chromosomes and maintaining chromosome structure. Moreover, topoisomerase II also has been identified as the primary cellular target for several widely used antineoplastic drugs. Before the physiological functions of topoisomerase II can be effectively dissected or its drug interactions fully exploited, it is imperative to understand the mechanism by which this important enzyme arries out its catalytic cycle. (shrink)

The continuing spread and development of electronic data interchange in health care settings is fuelling a significant global debate about the practicality, ethics, and legality of such a practice. The uncertainties implicit in this debate are particularly acute in the context of disease or population groups for whom multidisciplinary, multipleagency teamworking has become acknowledged as the “best practice” for providing effective and timely care or support. The greying of the population is a demographic phenomenon that will have a profound impact (...) on the health care system, social care agencies, and caregivers, and will require a greater degree of service coordination in order to meet the complex care needs of both care-receiver and caregiver. (shrink)

The continuing spread and development of electronic data interchange in health care settings is fuelling a significant global debate about the practicality, ethics, and legality of such a practice. The uncertainties implicit in this debate are particularly acute in the context of disease or population groups for whom multidisciplinary, multipleagency teamworking has become acknowledged as the “best practice” for providing effective and timely care or support. The greying of the population is a demographic phenomenon that will have a profound impact (...) on the health care system, social care agencies, and caregivers, and will require a greater degree of service coordination in order to meet the complex care needs of both care-receiver and caregiver. (shrink)

Several metabolites serve as substrates for histone modifications and communicate changes in the metabolic environment to the epigenome. Technologies such as metabolomics and proteomics have allowed us to reconstruct the interactions between metabolic pathways and histones. These technologies have shed light on how nutrient availability can have a dramatic effect on various histone modifications. This metabolism–epigenome cross talk plays a fundamental role in development, immune function, and diseases like cancer. Yet, major challenges remain in understanding the interactions between cellular metabolism (...) and the epigenome. How the levels and fluxes of various metabolites impact epigenetic marks is still unclear. Discussed herein are recent applications and the potential of systems biology methods such as flux tracing and metabolic modeling to address these challenges and to uncover new metabolic–epigenetic interactions. These systems approaches can ultimately help elucidate how nutrients shape the epigenome of microbes and mammalian cells. (shrink)

I provide an examination and comparison of modal theories for underwriting different non-modal theories of sets. I argue that there is a respect in which the `standard' modal theory for set construction---on which sets are formed via the successive individuation of powersets---raises a significant challenge for some recently proposed `countabilist' modal theories (i.e. ones that imply that every set is countable). I examine how the countabilist can respond to this issue via the use of regularity axioms and raise some questions (...) about this approach. I argue that by comparing them with the `standard' uncountabilist theory, a new approach that brings in arbitrariness rather than the strict controls of forcing is desirable. (shrink)